2016 Fiscal Year Final Research Report
Functional network of nascent protein and molecular chaperones
| Project/Area Number |
26830141
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | University of Hyogo |
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Principal Investigator |
Machida Kodai 兵庫県立大学, 工学研究科, 助教 (20553093)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 合成生物学 |
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| Outline of Final Research Achievements |
In this study, we established an in vitro protein synthesis/folding coupled system reconstituted with purified human translational factors and molecular chaperones. Using this system, we successfully identify the molecular chaperones that are essential for co- or post-translational folding of human nascent proteins. Thus, our in vitro approach can be a useful tool to analyze the molecular mechanisms of protein conformational disorders such as Alzheimer’s disease, Parkinson's disease and Huntington's disease.
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| Free Research Field |
タンパク質工学
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