2015 Fiscal Year Final Research Report
Comprehensive study of structure and dynamics of laminopathy-causing LMNA mutants for elucidation of Laminopathy
| Project/Area Number |
26840050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | NMR |
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| Outline of Final Research Achievements |
In order to demonstrate how structural and physicochemical changes of Lamin A(LMNA) are induced by laminopathy-causing mutations, we investigated tertiary structures and dynamics of LMNA Ig-like domain by NMR by developing the “MagRO-FLYA-CYANA” system for fully-automated NMR assignment and structure determination. As a result, we determined the tertiary structures of 5 mutants of the LMNA Ig-like domain. These mutants cause different types of laminopathy.
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| Free Research Field |
構造生命科学
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