2017 Fiscal Year Final Research Report
Functional analysis of a retroposon involved in corpus callosum development
| Project/Area Number |
26840117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Evolutionary biology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 発現制御 / 反復配列 / 脳梁 / レトロポゾン |
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| Outline of Final Research Achievements |
It has been reported that an AmnSINE1-derived sequence, AS021, serves as an enhancer of Satb2 in corpus callosum of mammals. However, its detailed molecular mechanism remains unknown. In this work, function of an AS021 binding protein and the expression pattern of the related genes in the AS021 deficient mice were revealed. These results will be a quite important basis for understanding of the impact of AmnSINE1-derived enhancers on the gene regulatory network during mammalian evolution.
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| Free Research Field |
進化生物学
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