Characterization of antigen sampling cells in gill epithelium of fish

2015 Fiscal Year Final Research Report

• Project/Area Number: 26850128
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Aquatic bioproduction science
• Research Institution: Tokyo University of Marine Science and Technology (2015); Fisheries Research Agency (2014)
• Principal Investigator: KATO GOSHI 東京海洋大学, その他部局等, 助教 (50624219)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 抗原取り込み / 鰓粘膜 / Aeromonas salmonicida / UEA-1 / 浸漬ワクチン / 次世代シークエンサー / フローサイトメトリー / 魚類免疫

Outline of Final Research Achievements

Bath-vaccination is a useful method to immunize small fish that injected vaccine is not suitable for. However, this method can be used for limited number of fish diseases. Vaccine antigens bath-vaccinated to fish are taken up by gill epithelial antigen sampling (GAS) cells. In this study, we revealed that GAS cell take up only bacterins which shows protective efficacy as bath-vaccine. Understanding a physiology of the GAS cells may contribute to expansion of the usage of bath-vaccination method.

Free Research Field

水圏生産科学