Elucidation of inflammatory mechanism and pathologic role in iron dysregulation in chronic liver diseases.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26850184
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Osaka Prefecture University
• Principal Investigator: Izawa Takeshi 大阪府立大学, 生命環境科学研究科(系), 准教授 (20580369)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 慢性肝疾患 / 鉄代謝 / 肝硬変 / 代謝性疾患 / 炎症

Outline of Final Research Achievements

Iron overload is considered as a risk factor for chronic liver diseases; however, the mechanism is still unclear. In this study, we showed that imbalance between macrophages and inflammatory cytokines is related to development of iron overload in the advanced stage of chronic liver disease in rats. We also showed that dietary iron overload suppresses liver injury in rats with chemically-induced liver cirrhosis whereas it enhances liver inflammation in rats with metabolic liver disease. These findings can be useful basic data for understanding the complex mechanism of progression of chronic liver diseases.

Free Research Field

獣医病理学