Study of norovirus gastroenteritis in cats: attempt to establish animal model for pathogenesis of norovirus infection

2015 Fiscal Year Final Research Report

• Project/Area Number: 26850185
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Kitasato University
• Principal Investigator: Takano Tomomi 北里大学, 獣医学部, 准教授 (20525018)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ノロウイルス / 動物モデル / 感染性胃腸炎 / 猫

Outline of Final Research Achievements

Norovirus (NoV) has been classified into 6 genogroups, GI-GVI. In the present study, we newly identified novel feline NoV (FNoV) M49-1 strain. Based on the results of the Simplot analysis, the FCoV M49-1 strain may have been produced by recombination between GIV.2 FNoV and GVI.1 CNoV. In addition, specific pathogen-free cats inoculated with the FNoV M49-1 strain developed gastroenteritis-like clinical symptoms, and the viral gene was detected in their feces and blood. Our results may be useful for studies on human and animal NoV.

Free Research Field

獣医感染症学、獣医ウイルス学