Characterization of canine novel mesenchymal stem cells adhering to adipocytes in bone marrow for clinical application in regenerative therapy.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26850192
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: The University of Tokyo
• Principal Investigator: Fujita Naoki 東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (10554488)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 間葉系幹細胞 / 犬 / 骨髄 / 再生医療

Outline of Final Research Achievements

We developed novel mesenchymal stem cells from canine bone marrow and named the cells as bone marrow per-adipocyte cells（BM-PACs). BM-PACs attached to adipocytes in bone marrow and have superior potentials as multipotent cells compared with conventional canine bone marrow mesenchymal stem cells (BMMSCs). Additionally, BM-PACs showed higher expression of hepatocyte growth factor (HGF), which is known to have great healing effects on injured tissues, than BMMSCs. After locally injected into a mouse skin injury model, BM-PACs migrated toward the injured area and showed HGF expression. In addition, intravenously injected BM-PACs also migrated toward injured area and showed HGF expression. Thus, our results suggest that stem cell therapy using BM-PACs offer a healing effect through the supply of HGF to the injured site.

Free Research Field

再生医療