Effect of perichondrium-induced cell sheet flap on articular cartilage regeneration

2017 Fiscal Year Final Research Report

• Project/Area Number: 26850198
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Obihiro University of Agriculture and Veterinary Medicine (2017); University of Miyazaki (2014-2016)
• Principal Investigator: TSUZUKI Nao 帯広畜産大学, 畜産学部, 准教授 (60725430)
• Research Collaborator: KUSANO Kanichi ; Kanbayashi Yoshinori
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 関節軟骨 / 細胞シート / 活性酸素

Outline of Final Research Achievements

This study aimed at articular cartilage regeneration with a cell sheet, which processed cells into sheets. However, revise of the plan was necessary due to the problem that became clear after the start of the research. Among these proved problems, we evaluated the production of reactive oxygen at the site of articular cartilage injury in this study. As a result, it was showed that reactive oxygen is generated in the site of articular cartilage injury site. Although this study did not reach the stage showing the effectiveness of the cell sheet for articular cartilage regeneration, it was possible to clarify some of the problems to be solved before cell sheet application. It was thought to be necessary to solve the problems clarified from this study in order to show the usefulness of the cell sheet for articular cartilage regeneration.

Free Research Field

外科学、画像診断学