2016 Fiscal Year Final Research Report
Analysis of antiviral activity of 25-hydroxycholesterol
| Project/Area Number |
26860050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Shibata Norihito 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官 (30391973)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 酸化コレステロール |
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| Outline of Final Research Achievements |
Although it is well known that many viruses can cause severe diseases, existing drugs against viruses are not sufficient and development of novel anti-virus drugs is required. Previously, I found that 25-hydroxycholesterol (25OHC) can inhibit virus replication without affecting on the viability of host cells. In this study, I investigated the molecular mechanism how 25OHC is recognized by the host cells, and how 25OHC induces the expression of specific stress-related genes. These results suggest that 25OHC may be a promising target for development of a novel anti-virus drug.
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| Free Research Field |
生化学
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