2015 Fiscal Year Final Research Report
Elucidation of pathogenic mechanism of schizophrenia focused on intracellular signaling by quantitative proteomics
| Project/Area Number |
26860057
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
Hirayama Mio 熊本大学, その他の研究科, 助教 (90706483)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | プロテオミクス / ネットワーク解析 / 統合失調症 |
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| Outline of Final Research Achievements |
We identified differentially expressed proteins in the brains of schizophrenia patients by high-precision quantitative mass spectrometric analysis. A network analysis based on protein-expression data identified a decrease in “GNA13-ERK-eIF4G2” signaling. A co-expression analysis using the protein expression levels determined by targeted proteomics was performed, whereby the signaling proteins significantly correlated between upstream and downstream proteins. These results suggest a correlation between attenuation of the molecular network involving ERK1 in the prefrontal cortex of schizophrenia patients and schizophrenia pathology.
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| Free Research Field |
プロテオミクス
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