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2015 Fiscal Year Final Research Report

Synthesis and evaluation of new non steroidal anti inflammatory drugs for clinically useful

Research Project

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Project/Area Number 26860082
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Research InstitutionShujitsu University

Principal Investigator

Yamakawa Naoki  就実大学, 薬学部, 講師 (20583040)

Project Period (FY) 2014-04-01 – 2016-03-31
Keywords医薬品探索
Outline of Final Research Achievements

The present study aimed at the elucidation of a relationship between a gene induced by NSAIDs-depend and pharmacological action, and at the synthesis and evaluation of a clinically useful compounds by using organic synthetic technique. Particularly, these trials could be useful to develop of pharmaceutical compounds having more effective and high-safety as drug by analyzing the molecular mechanism in conjunction with the side effect in detail. In this study, we have clarified that the compounds which is high-selectivity to the cyclooxygenase have high membrane permeability than non-selectivity compounds.

Free Research Field

医歯薬学

URL: 

Published: 2017-05-10  

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