The maximam effect and the velocity of antihypertensive effects of drugs for hypertension determined by home blood pressuremeasurements

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860093
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: Satoh Michihiro 東北大学, 大学病院, 特別研究員(PD) (70717892)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 降圧薬 / 薬効評価 / 高血圧 / アンジオテンシンⅡ受容体拮抗薬

Outline of Final Research Achievements

We aimed to examine the blood pressure (BP)-lowering effect and the time to attain the maximal antihypertensive effect (stabilization time) of several angiotensin II receptor blockers (ARBs) based on home BP measurements. We surveyed consecutive newly diagnosed, untreated patients with hypertension who started the treatment with a mid-level dose of one of seven ARBs. All study participants measured home BP in the morning for at least 1 week during an untreated period and 4 weeks during the treatment period (total n=232; age, 62.2 years; 50.9% men; home SBP/DBP, 151.6/90.0 mmHg). The maximum effect / the stabilization time based on home systolic BP were 15.3 mmHg/ 7.1 days for azilsartan 20 mg, 14.7 mmHg/ 9.2 days for olmesartan 20 mg, 13.7 mmHg/ 8.9 days for telmisartan 40 mg, 12.9 mmHg/ 11.0 days for candesartan 8 mg, 11.9 mmHg/ 22.8 days for losartan 50 mg, 8.2 mmHg/ 4.7 days for irbesartan 100 mg, and 7.9 mmHg/ 7.1 days for valsartan 80 mg.

Free Research Field

疫学、医療薬学