2017 Fiscal Year Final Research Report
The roles of PXR in immune responses
| Project/Area Number |
26860122
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
SAEKI Mayumi 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員 (00462771)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | PXR / T細胞 |
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| Outline of Final Research Achievements |
PXR, a member of the nuclear receptor superfamily, is expressed in immune cells, but the role of PXR in T lymphocyte remains unknown. Thus, we determined the roles of PXR in T lymphocyte. The combination of PMA and ionomycin induced PXR expression in human T cell acute leukemia Jurkat cells. Rifampicin, one of selective activators of PXR, increased PMA/ionomycin-mediated IL-2 expression, while expression of IL-4 and IL17A were nearly unchanged.
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| Free Research Field |
アレルギー学
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