Characterization of human fetal appendages-derived Muse cells as a new source of Muse cells for regenerative medicine

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860126
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Tohoku University
• Principal Investigator: Kushida Yoshihiro 東北大学, 医学(系)研究科(研究院), 助教 (10707003)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: Muse細胞 / 多能性幹細胞 / 間葉系幹細胞 / 胎児付属物

Outline of Final Research Achievements

Human umbilical cord tissue-derived Muse cells (UC-Muse cells) resided sparsely in Wharton’ jelly and expressed pluripotent markers such as Nanog and Oct3/4. These cells exhibited self-renewal and triploblastic differentiation under both spontaneous and induced differentiation condition. Furthermore, these cells didn’t develop into teratomas when transplanted into the testes of immunodeficient mice (SCID mice). These results suggest that UC-Muse cells exhibit the ability similar to that of adult human tissues and are useful as a new source of Muse cells for regenerative medicine.

Free Research Field

医歯薬学