Cellular dynamics of the anterior second heart field during heart development

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860127
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology)
• Research Institution: National Cardiovascular Center Research Institute (2015); Tohoku University (2014)
• Principal Investigator: Watanabe Yusuke 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (20562333)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 心臓 / 発生 / 細胞動態

Outline of Final Research Achievements

In this study, I aimed to understand cellular dynamics of anterior second heart field (aSHF) cells which contribute to the outflow tract and right ventricle of the heart.
I observed mouse embryos which expresses fluorescent proteins in cardiac mesoderm. As a result, aSHF region seemed to contribute to the outflow tract with dynamic remodeling of tissues. This suggests that the outflow tract is formed by incorporation of aSHF region to the heart with tissue remodeling of embryo.

Free Research Field

発生生物学