Is hypertension due to sleep apnea caused by hyperactivation of sympathetic nervous activity?

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860165
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Nara Women's University
• Principal Investigator: YOSHIMOTO MISA 奈良女子大学, 生活環境科学系, 准教授 (20418784)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 睡眠時無呼吸症候群 / 高血圧 / 神経性動脈圧調節 / 腎交感神経活動 / ラット

Outline of Final Research Achievements

Sleep apnea syndrome (SAS) is complicated by cardiovascular diseases. Activation of sympathetic nerve activity has been suggested to contribute the cardiovascular diseases, while there has been little direct evidence on sympathetic nerve activity (SNA). We measured directly response of SNA to elucidate causal linkage between hypertension and activation of SNA in response to SAS. To simulate SAS in rats, Intermittent hypoxia (IH) and a balloon implanted in the trachea induction of apnea.
Arterial pressure (AP) and renal SNA (RSNA) increased immediately after the onset of exposed 5% IH every time, but baselines did not change. While, AP and RSNA increased immediately after the onset of the obstruction and baseline of RSNA increase day bay day.

Free Research Field

環境生理