Analysis of CD47-SIRPalpha system, an intercellular signaling system, in immune regulation

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860210
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Kobe University
• Principal Investigator: Kotani Takenori 神戸大学, 医学(系)研究科(研究院), 助教 (40455960)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 細胞間シグナル伝達 / 樹状細胞 / チロシンリン酸化・脱リン酸化 / SIRPα / CD47

Outline of Final Research Achievements

Signal regulatory protein α (SIRPα), an immunoglobulin superfamily protein that is expressed predominantly in dendritic cells (DCs) or macrophages, mediates cell-cell signaling by interacting with its ligand CD47, another immunoglobulin superfamily protein. In this study, I showed that mice lacking SIRPα specifically in DCs manifested a marked reduction of CD4-positive conventional DCs in the secondary lymphoid organs, as well as of Langerhans cells in the epidermis. Thus, these findings suggest that SIRPα on DCs is indispensable for homeostasis of DCs in the secondary lymphoid organs and skin.

Free Research Field

生化学・分子生物学