Ribosomal RNA gene mutation in Human Malignancies

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860233
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Niigata University
• Principal Investigator: OHASHI Riuko 新潟大学, 医歯学系, 助教 (20447600)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: リボソーム遺伝子 / LXRα / 肺癌 / 遺伝子変異 / 遺伝子多型

Outline of Final Research Achievements

In this study, we identified new somatic mutations in proximity to ribosomal RNA gene transcription start site in two cases (5%) of 40 lung cancer patients by PCR-direct sequence method. To determine the relationship between clinicopathological significance and ribosomal RNA gene mutation, sequence analysis of more patients are ongoing.

Free Research Field

人体病理学