Pathomechanisms of cerebral amyloid angiopathy-related inflammation

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860234
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Kanazawa University
• Principal Investigator: Sakai Kenji 金沢大学, 附属病院, 助教 (00572306)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳アミロイドアンギオパチー / 炎症

Outline of Final Research Achievements

Cerebral amyloid angiopathy (CAA) characterized by deposition of amyloid β protein in the vessel walls in the central nervous system rarely develops inflammation and/or vasculitis (CAA-related inflammation). Although CAA is commonly observed in elder people, details of the pathomechanisms of CAA-related inflammation are still uncertain. In this study, I have collected samples from the patients with CAA and CAA-related inflammation throughout Japan, such as cerebrospinal fluid, brain tissue, and DNA. Cerebrospinal fluid samples in patients with CAA-related inflammation demonstrated alteration of inflammatory cytokines. These data disclosed pathomechanisms of CAA-related inflammation.

Free Research Field

神経病理学