Establishment and pathological analysis of novel model mice of systemic chronic inflammation and progeria

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860263
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Osaka University
• Principal Investigator: Kawase Ryota 大阪大学, 医学(系)研究科(研究院), 特任研究員 (60727650)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: progranulin / 慢性炎症 / 老化

Outline of Final Research Achievements

We revealed that Progranulin (PGRN)・ApoE double KO mice (DKO) died significantly earlier than ApoE KO and often suffered joint swelling and dermatitis, which is considered to be the manifestations of chronic inflammation. Therefore, we hypothesize that DKO might be novel model mice of systemic inflammation and progeria. PGRN have been already reported to bind TNF receptors (TNFRs) and exert anti-inflammatory effects. We find possibility of another pathway other than TNFRs in TNFR KO mice. We also revealed that macrophage-derived PGRN plays important athero-protective roles by using bone marrow transplantation method. And we found that PGRN binding HDL has an anti-oxidative effect. Taken together, PGRN might play essential roles in anti-inflammation and successful aging.

Free Research Field

動脈硬化