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2015 Fiscal Year Final Research Report

Cancer immunosurveillance mediated by innate immune receptors

Research Project

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Project/Area Number 26860316
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionThe University of Tokyo

Principal Investigator

Ikushima Hiroaki  東京大学, 生産技術研究所, 助教 (80719154)

Project Period (FY) 2014-04-01 – 2016-03-31
Keywords抗腫瘍免疫 / 自然免疫
Outline of Final Research Achievements

The critical role of innate immune receptors in mediating innate and adaptive immune responses against invading pathogens is well known. However, it has been enigmatic if and how these receptors contribute to anti-tumor responses. In this study, we demonstrated that the dendritic cells and macrophages produce an innate immune receptor called Dectin-1 which recognizes a molecule found on the surface of some, but not all, types of tumor cell. In doing so, Dectin-1 activates a critical signaling pathway and directs the activity of the natural killer cells so that they can effectively kill tumor cells.

Free Research Field

腫瘍学

URL: 

Published: 2017-05-10  

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