2015 Fiscal Year Final Research Report
Cancer immunosurveillance mediated by innate immune receptors
| Project/Area Number |
26860316
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 抗腫瘍免疫 / 自然免疫 |
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| Outline of Final Research Achievements |
The critical role of innate immune receptors in mediating innate and adaptive immune responses against invading pathogens is well known. However, it has been enigmatic if and how these receptors contribute to anti-tumor responses. In this study, we demonstrated that the dendritic cells and macrophages produce an innate immune receptor called Dectin-1 which recognizes a molecule found on the surface of some, but not all, types of tumor cell. In doing so, Dectin-1 activates a critical signaling pathway and directs the activity of the natural killer cells so that they can effectively kill tumor cells.
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| Free Research Field |
腫瘍学
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