Analysis of the role of CD3 molecule expressing in germinal center B cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860327
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Kyoto University
• Principal Investigator: Todo Kagefumi 京都大学, 医学研究科, 特定研究員 (50452561)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: B細胞 / 胚中心

Outline of Final Research Achievements

The molecular mechanisms of positive and negative selection of B cells in germinal center during the immune response have not been fully elucidated. It is important to understand these mechanisms because it has been thought that the dysregulation of the B cells selection in germinal center leads to autoimmune disease.
In this study, I revealed that CD3 molecule that is a major component of T cell antigen receptor complex expressed in germinal center B cells. In addition, these CD3-expressing B cells were highly sensitive apoptosis. Moreover, markedly increased levels of antigen-specific and auto-reactive antibodies were both detected when mice harboring CD3e-deficient B cells and normal T cells were immunized.
These results suggest that CD3e expressed in B cells plays critical roles in germinal center B cell selection during the immune response.

Free Research Field

免疫学