2016 Fiscal Year Final Research Report
Development of a new therapeutic drug for dementia using a novel neuroprotective compound J147
| Project/Area Number |
26860358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Musashino University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 認知症 / J147 / 記憶 |
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| Outline of Final Research Achievements |
We have recently found that J147, a novel neuroprotective compound, facilitates long-term potentiation in rat hippocampal slices and enhances object recognition in rats. J147 could be useful in the development of therapeutic drugs for senile dementia. In this study, we showed that J147 rescued cognitive deficits in Alzheimer’s disease model mice by modulating several signaling pathways including the CREB-BDNF pathway in the hippocampus.
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| Free Research Field |
応用薬理学
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