Genome-wide association analyses of copy number variations in sensitivity to addictive substances and vulnerability to dependence

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860360
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: NISHIZAWA Daisuke 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (80450584)
• Research Collaborator: IKEDA Kazutaka
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 薬物依存 / 薬物感受性 / 薬物感受性・依存症脆弱性個人差の遺伝要因 / コピー数多型・変異 / ゲノムワイド関連解析

Outline of Final Research Achievements

Comprehensive analyses were conducted in subjects who underwent painful cosmetic orthognathic surgery involving opioid administration to investigate associations between copy number variations (CNVs) throughout the human genome and postoperative 24-h opioid requirements or preoperative analgesic effects of fentanyl as indices of opioid sensitivity. As a result, CNVs around the gene regions of the CHSY3 and HINT1 on chromosome 5 and the AGBL4, C1orf165, and ELAVL4 on chromosome 1 were identified as the best candidates for postoperative 24-h opioid requirements. In addition, CNVs around the gene regions of the FAM5B and SEC16B on chromosome 1 and the GBE1 and ADM2 on chromosome 3 were identified as the best candidates for preoperative analgesic effects of fentanyl.

Free Research Field

分子精神医学