Elucidation of the irregular erythrocyte antibodies-related delayed hemolytic transfusion reaction - Promotion of the prospective collaborative study -

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860366
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Fujihara Harumi 浜松医科大学, 医学部附属病院, 臨床検査技師 (50643350)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 赤血球不規則抗体 / 輸血 / 前方向多施設共同研究 / 遅発性溶血性輸血副作用

Outline of Final Research Achievements

The registrant of this study was 331 cases. 257 cases performed irregular erythrocyte antibodies after transfusion or parturition (78%). The positive conversions were identified 4 cases (3.3%) in RBC transfusion group and no cases in parturition group. The irregular erythrocyte antibodies in these 4 cases were as follows : anti-E, anti-Jka, anti-C, anti-Lea. As for the gender, 3 cases were women. As for the effect of pregnancy history, 2 cases were having pregnancy history and 1 case was primiparity.
The problem of the future pilot study refines a population when we calculate the positive conversions ratio of the irregular erythrocyte antibody. The true positive conversions ratio of each irregularity erythrocyte antibody is detected by limiting the population which should follow. After the review of the population, we recruit participating institutions from an irregular erythrocyte antibody research group and conduct the pilot study of the collaborative study.

Free Research Field

輸血・細胞治療