2015 Fiscal Year Final Research Report
The development of the anti-angiogenic factor VEGF-A165b quantification methods for cardiovascular disease.
| Project/Area Number |
26860367
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
KIKUCHI RYOSUKE 名古屋大学, 医学部附属病院, 臨床検査技師 (30721435)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | VEGF-A / 臨床検査医学 / VEGF-A165b / 血管新生 / 抗血管新生因子 |
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| Outline of Final Research Achievements |
The VEGF-A165 (pro-angiogenic) and VEGF-A165b (anti-angiogenic), only the sequence of 6 amino acid residues of the C- terminal side is different. The current ELISA system of VEGF-A does not discriminate between different VEGF-A isoforms (pro- or anti-angiogenic forms). Here, we made the development of VEGF-A165b specific ELISA system, and the clarified the molecular mechanisms of VEGF-A165b.
Moreover, the urinary VEGF-A165b concentration was found to be useful for the development assessment of renal dysfunction.
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| Free Research Field |
臨床検査医学
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