The development of new examination in autoimmune thyroid disease used by Toll- like receptors

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860369
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Osaka University
• Principal Investigator: Inoue Naoya 大阪大学, 医学部附属病院, 臨床検査技師 (80710269)
• Research Collaborator: IWATANI Yoshinori 大阪大学, 大学院 医学系研究科 保健学専攻 生体情報科学講座, 教授 ; WATANABE Mikio 大阪大学, 大学院 医学系研究科 保健学専攻 生体情報科学講座, 准教授 ; HIDAKA Yoh 大阪大学, 医学部附属病院臨床検査部
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: TLR / 遺伝子多型 / 発現解析 / 検査法

Outline of Final Research Achievements

In the TLR4 rs41426344 polymorphism, GC + CC genotypes and C allele were more frequent in the mild HD group compared to the severe HD group.The ratio of intracellular TLR7 and intracellular TLR9 intensities in B cells was lower in patients with GD in remission than in patients with intractable GD.In conclusion, the GC + CC genotypes of the TLR4 rs41426344 polymorphism protect against thyroid destruction and are less prone to hypothyroidism.The ratio of intracellular TLR7 and intracellular TLR9 intensities in B cells was associated with the development and intractability of GD and UNC93B1 polymorphisms were associated with the development of GD.

Free Research Field

臨床検査