Associtation circulating miRNAs and lifestyle : aiming at application to clinical examination

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860375
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Fujita Health University
• Principal Investigator: Yamada Hiroya 藤田保健衛生大学, 医学部, 講師 (80610352)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: microRNA / Circulating miRNA / Serum miRNA / 遺伝子検査 / 生活習慣 / 変動要因 / バイオマーカー

Outline of Final Research Achievements

Circulating micro (mi)RNA profiles are influenced by various medical conditions, and miRNAs have been examined as potential biomarkers for cancer, cardiovascular disease, and diabetes. However, few studies have investigated whether circulating miRNAs and life style factors, such as cigarette smoking and drinking, are correlated. Our aim was to determine the association between smoking status and expression of various miRNAs in a Japanese population sample. We found that life style factors is associated with elevated expression of various serum miRNAs.
Our results suggest that it is necessary to consider the confounding effect caused by lifestyle when evaluating expression of serum miRNAs for diagnosing pathological conditions.

Free Research Field

病態検査学