2015 Fiscal Year Final Research Report
Establishment of scientific basis for iPS cell-rerived granulocyte transfusion strategy
| Project/Area Number |
26860474
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | iPS細胞 / 顆粒球輸注 / 顆粒球輸血 / サイトカイン / がん / 化学療法 |
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| Outline of Final Research Achievements |
When the patients with cancer receive chemotherapies, white blood cells usually decrease and they have high risk for severe infection, which affect the treatment outcome. We need to have some novel strategies against this problem and granulocyte transfusion therapy is one of the excellent candidates to solve the issue. However, it is currently not widely used in the clinical setting because of physical and psychologic burdens and risk of donors. We developed a novel strategy to limitlessly obtain iPS cell-derived granulocytes by combining several gene transduction and cytokines for iPS cells.
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| Free Research Field |
血液・腫瘍
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