The role of AMPA receptor GluR1 for rapid-acting antidepressant behavior

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860481
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Yamaguchi University
• Principal Investigator: HOBARA Teruyuki 山口大学, 医学部, 特別医学研究員 (20637970)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: CaMKIIβ / ストレス / うつ病 / 抗うつ作用 / GluR1

Outline of Final Research Achievements

aThe aim of this study is to elucidate the molecular mechanism underlying HDAC inhibitor SAHA-induced rapid-acting antidepressant behavior. We found that SAHA increases mRNA expression of CaMKIIβ, which in turn enhances the phosphorylation of AMPA receptor GluR1, resulting in increased trafficking of GluR1 in synaptic membrane in the hippocampus of mice treated with SAHA. Together, these results suggest CaMKIIβ-GluR1 signaling might be associated with SAHA-induced rapid-acting antidepressant behavior.

Free Research Field

分子精神医学