2015 Fiscal Year Final Research Report
Increased TNF-R1 expression as a promising biomarker of human colorectal cancer
| Project/Area Number |
26860519
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 大腸癌 / バイオマーカー / TNF-α / TNF-R1 |
|---|
| Outline of Final Research Achievements |
The proinflammatory cytokine, tumor necrosis factor (TNF)-α, is a major mediator of cancer-related inflammation. However, little has been reported on the relation between TNF-α and sporadically occurring colorectal neoplasms. The aim of this study was to determine the expression statuses of TNF-α and its receptors in colorectal cancer. We measured the serum concentrations of TNF-α and those of its receptors in colorectal cancer patients and healthy controls. The serum levels of sTNF-R1 in cancer patients were significantly higher as compared with those in the control group. ROC analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928) in patients for the diagnosis of colorectal cancer. These results suggest that TNF-R1 may only be a promising biomarker of colorectal cancer, but also play an important role in the very early stage of colorectal carcinogenesis.
|
| Free Research Field |
消化器内科学
|
