2016 Fiscal Year Annual Research Report
Study on miRNA expression and single nucleotide polymorphisms in hepatocellular carcinoma after HCV eradication
| Project/Area Number |
26860522
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| Research Institution | Osaka City University |
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Principal Investigator |
HOANG HAI 大阪市立大学, 大学院医学研究科, 研究員 (60623246)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | HCC SNP |
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| Outline of Annual Research Achievements |
- We measured soluble MICA protein by ELISA.
- Of the 4 SNPs analysed, MICA, DEPDC5, HCP5, and PNPLA3, only the MICA genotypes were significantly associated with development of HCC (p = 0.0185). The major (MA), hetero (HE), and minor (MI) genotypes occurred in 40%, 41%, and 19% of HCC patients and in 43%, 47%, and 10% of non-HCC patients, respectively. Interestingly, the MICA genotype was significantly correlated with soluble MICA protein levels.
- We have submitted manuscript "Polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with chronic hepatitis C-related hepatocellular carcinoma" to journal Scientific Reports. We are waiting for the decision.
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[Journal Article] 4.Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with HCV genotype 1b2016
Author(s)
Tamori A, Yoshida K, Kurai O, Kioka K, Hai H, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N
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Journal Title
Hepatol Res.
Volume: 46
Pages: 1311-1320
DOI
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Changes in NS3/4A and NS5A resistance-associated variants of hepatitis C virus after treatment failure with direct-acting antiviral(s)2016
Author(s)
Hai H, Yoshida K, Tamori A, Enomoto M, Morikawa H, Kozuka R, Teranishi Y, Motoyama H, Kawamura E, Hagihara A, Murakami Y, Thuy LTT, Kawada N
Organizer
AASLD 2016 Annual Meeting
Place of Presentation
Boston, MA, USA
Year and Date
2016-11-11 – 2016-11-15
Int'l Joint Research / Invited
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