Study on miRNA expression and single nucleotide polymorphisms in hepatocellular carcinoma after HCV eradication

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860522
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: HOANG HAI 大阪市立大学, 大学院医学研究科, 研究員 (60623246)
• Co-Investigator(Renkei-kenkyūsha): KAWADA Norifumi 大阪市立大学, 大学院医学研究科, 教授 (30271191)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: HCC SNP

Outline of Final Research Achievements

Of the 4 SNPs analysed, only the MICA genotypes were significantly associated with development of HCC (p = 0.0185). The major (MA), hetero (HE), and minor (MI) genotypes occurred in 40%, 41%, and 19% of HCC patients and in 43%, 47%, and 10% of non-HCC patients, respectively. Interestingly, the MICA genotype was significantly correlated with soluble MICA protein levels. In patients older than 70 years, the MI genotype was significantly associated with HCC development. In addition, the MI genotype was related to HCC development when the platelet count range was 10-15 × 104/μL but not when the range was less than 10 or greater than 15 × 104/μL. Thus, polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with HCC development in Japanese patients with chronic HCV infection, particularly older patients or patients with fibrosis.

Free Research Field

医歯薬学