2015 Fiscal Year Final Research Report
Interaction of miR-221/222 and adipocytokine signaling in esophageal adenocarcinoma
| Project/Area Number |
26860527
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
TSUGAWA Hitoshi
SUZUKI Hidekazu
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 食道腺がん / 中心性肥満 / アディポネクチン / マイクロRNA |
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| Outline of Final Research Achievements |
Esophageal adenocarcinoma, which is rapidly increasing in Western countries, is one of the complications of gastroesophageal reflux disease. Bile reflux and central obesity are major risk factors for esophageal adenocarcinoma. In general, plasma adiponectin levels are decreased through the progression of central obesity. We had reported that bile acids contribute to carcinogenesis through the activation of nuclear bile acid receptor (FXR) and the enhancement of miR-221/222. Herein, we identified that miR-221/222 enhance the expression of COX-2 in esophageal epithelial cells. On the other hand, COX-2 expression was suppressed during exposure to adiponectin receptor agonist. These results suggest adiponectin receptor agonist might work as a chemopreventive agent for esophageal adenocarcinoma among high-risk individuals with central obesity.
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| Free Research Field |
消化器内科学
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