2015 Fiscal Year Final Research Report
The role of basophils in bleomycin induced lung fibrosis
| Project/Area Number |
26860601
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TATEISHI Tomoya 東京医科歯科大学, 医学部附属病院, 助教 (40645636)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 間質性肺炎 / 好塩基球 |
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| Outline of Final Research Achievements |
Depletion of basophils augmented lung fibrosis induced by bleomycin in histological analysis. Microarray analysis revealed that Hmgb1 gene expression is significantly augmented in basophil-depleted mice. Besides, Hmgb1 gene expression is also augmented in IL4-depleted mice and IL4 receptor knock out mice. These findings support the hypothesis that basophils have anti-fibrotic role through suppressing HMGB1 production.
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| Free Research Field |
間質性肺炎
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