• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2015 Fiscal Year Final Research Report

Development of novel molecular targeted therapy against small-cell lung cancer

Research Project

  • PDF
Project/Area Number 26860606
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionOsaka University

Principal Investigator

MINAMI TOSHIYUKI  大阪大学, 医学(系)研究科(研究院), 助教 (00705113)

Co-Investigator(Kenkyū-buntansha) MORIMURA OSAMU  大阪大学, 大学院医学系研究科, 院生 (80743765)
Project Period (FY) 2014-04-01 – 2016-03-31
Keywords小細胞肺癌 / 抗癌剤耐性 / 分子標的治療 / HER2 / EphA2
Outline of Final Research Achievements

Therapeutic strategy against small-cell lung cancer (SCLC) has not improved over the last two decades. We examined the potential of HER2 and EphA2 as therapeutic targets in SCLC. We first evaluated HER2 expression by immunohistochemistry. HER2 expression was detected in 28% of diagnostic biopsy SCLC specimens. Then, we performed trastuzumab plus irinotecan combination therapy in two patients with HER2-positive SCLC. This combination therapy resulted in successful disease control in both patients. We next validated the antitumor activity of trastuzumab emtansine (T-DM1) in SCLC. T-DM1 induced apoptosis and suppressed the growth of HER2-positive irinotecan resistant SCLC xenografts in mice. We further evaluated the biological effects of EphA2 inhibition. EphA2 knockdown and functional inhibition by dasatinib brought about senescence in EphA2-positive SCLC cells, and inhibited their proliferation.
These results indicate that HER2 and EphA2 could be novel therapeutic candidates in SCLC.

Free Research Field

医歯薬学

URL: 

Published: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi