Analysis of novel innate immune receptor which recognizes influenza virus and endogenous ligand

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860613
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Kitasato University
• Principal Investigator: UEMATSU Takayuki 北里大学, 北里大学メディカルセンター, 上級研究員 (90414060)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 自然免疫 / 肺炎 / インフルエンザウイルス

Outline of Final Research Achievements

We focused on the function of ITAM-coupled receptor IgSFR2 which recognizes influenza virus (IFV), and analyzed the role for innate immune activation through the IgSFR2-mediated pathway in IFV infection. We revealed that activation of innate immunity through the IgSFR2-mediated pathway in mainly plasmacytoid dendritic cells is involved in the excessive inflammation in IFV-infected lungs. And we founded that influenza pneumonia was dramatically attenuated in Igsfr2-deficient mice, which showed improved survival rate compared with control mice. Furthermore, we clarified that IgSFR2 recognizes endogenous ligand, i.e., lipids or carbohydrates derived from dead cells due to IFV infection.

Free Research Field

免疫学