2015 Fiscal Year Final Research Report
Role of FBXO17 in EGFR mutation positive NSCLC
| Project/Area Number |
26860614
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
HAMAMOTO JUNKO 慶應義塾大学, 医学部, 特任助教 (40570239)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | EGFR |
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| Outline of Final Research Achievements |
We found that knockdown of FBXO17 induced cell growth arrest in 6 lung cancer cell lines out of tested 8 cell lines. Not all but some lung cancer cell lines showed up-regulation of phosphorylated ERK by FBXO17 overexpression. Moreover, G1/S cell cycle checkpoint was disrupted by FBXO17 overexpression in all tested lung cancer cell lines.
We could not identify the binding protein of FBXO17, but we've suggested that FBXO17 is an important gene implicating in cell growth, cell cycle and EGFR pathway.
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| Free Research Field |
肺癌
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