2015 Fiscal Year Final Research Report
Research for developing a novel therapy for renal diseases targeting TRPV4
| Project/Area Number |
26860626
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | TRPV4 / 炎症 / 慢性腎臓病 |
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| Outline of Final Research Achievements |
TRPV4, which is expressed in renal collecting duct cells, has pro-inflammatory effects. This molecule was investigated as a novel therapeutic target for chronic kidney disease, for which no decisive therapy exists now. In murine cultured collecting duct cells, TRPV4 agonists induced inflammation, whereas TRPV4 inhibitors suppressed inflammation provoked by lipopolysaccharide and damage-associated molecular pattern. In murine kidney aseptic inflammation and fibrosis models, TRPV4 knockout mouse kidney show both promoted and suppressed inflammation, according to different models and postoperative days. In summary, these results laid the foundation to target TRPV4 for a novel therapy of renal diseases.
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| Free Research Field |
腎臓病学
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