2015 Fiscal Year Final Research Report
Physiological function of unfolded protein response in kindney
| Project/Area Number |
26860641
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 生理的小胞体ストレス応答 / 腎臓 |
|---|
| Outline of Final Research Achievements |
The unfolded protein response (UPR) implicates in renal diseases. However, recent studies indicated that physiological UPR, which is known as weak signaling pathway, associated to various biological phenomena. Here, this study investigated that activation mechanisms of physiological UPR in kidney and especially focused on regulator and adaptor proteins of ER stress sensors. I found that (1) a novel regulator proteins were identified, (2) down-regulation of regulator proteins was alleviated stress-induced renal injury and apoptosis in both in vitro and in vivo, (3) identified regulator proteins interacted with ER stress sensors, which was substantially enhanced during stress condition. These data suggest a possibility that the proper activation of physiological UPR contribute to cell homeostasis in kidney.
|
| Free Research Field |
医歯薬学
|
