innate T cells in multiple sclerosis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860654
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Hokkaido University
• Principal Investigator: Hirotani Makoto 北海道大学, 医学(系)研究科(研究院), 助教 (60399920)
• Co-Investigator(Renkei-kenkyūsha): SASAKI HIDENAO 北海道大学, 大学院医学研究科, 教授 (80281806)
• Research Collaborator: WAKAO HIROSHI 北海道大学, 大学院医学研究科, 准教授 (10280950)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 神経免疫 / 多発性硬化症 / ｉｎｎａｔｅ Ｔ細胞

Outline of Final Research Achievements

We aimed to analyze the function of mucosal associated invariant T (MAIT) cells in multiple sclerosis. The frequency of MAITs, the cell surface antigen expression profiles in MAITs, and the cytokine production from MAITs in the peripheral blood of healthy donors (HD), disease modifying therapy-free (non-DMT), Interferon-beta, and FTY720-treated patients were analyzed. Although there was little difference in the frequency of MAITs between HD and non-DMT subjects, FTY720 has increased the relative frequency of MAITs in a time-dependent fashion.

Free Research Field

医歯薬学