2015 Fiscal Year Final Research Report
The exercise regulated hepatic metabolism and the role of IL-6/STAT3/FGF21
| Project/Area Number |
26860690
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 運動 / 肝臓 / 骨格筋 |
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| Outline of Final Research Achievements |
Exercise can improve hepatic metabolism. We investigate its mechanism focusing on IL-6, which is excreted from skeletal muscle by exercise, and on STAT3 and FGF21, which activate hepatic glucose and lipid metabolism, and explore an exercise-mimetic treatment.
We found that exercise increase the hepatic IRS-2 and phosphorylation of STAT3 in mice. Exercise also increases hepatic FGF21 expression, which was canceled by neutralization with anti-IL-6 antibody. We are investigating further mechanism by which exercise improve hepatic metabolism through IL-6/STAT3/FGF21 in vitro and in vivo.
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| Free Research Field |
肥満、糖尿病
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