2015 Fiscal Year Final Research Report
Alteration of stress response by a histone methylation abnormality in hematopoietic stem cells
| Project/Area Number |
26860729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Shiga University of Medical Science (2015)
Kyoto University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 造血分化 / ヒストンメチル化 |
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| Outline of Final Research Achievements |
In the current study, we focused the hematological function of a histone lysine demethylase, KDM4B, that is reported to be associated with DNA-damage stress and hypoxia stress and is overexpressed in primary acute myeloid leukemia cells. Knockdown or overexpression of KDM4B did not enhance the proliferation capacity nor affect response against DNA-damage stress in leukemmia cells. However, overexpression of KDM4B in hematopoietic stem cells promoted the differentiation towards granulocytes. These data suggest that KDM4B could be involved with myeloid differentiation.
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| Free Research Field |
血液腫瘍学
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