2015 Fiscal Year Final Research Report
A basic study about the immune regulation by thymus-derived regulatory T cells induced in vivo
| Project/Area Number |
26860748
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kanazawa University |
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Principal Investigator |
Hamano Ryoko 金沢大学, 医学系, 協力研究員 (10623655)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 制御性T細胞 / 胸腺 / 炎症 |
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| Outline of Final Research Achievements |
It is reported that a combined i.v. administration of antigen and IL-2-anti-IL-2 Ab immune complexes (IL-2 ICs) efficiently expands antigen-specific Treg cells in the thymus and induces their migration into peripheral blood. In this study, we explored that the expanded antigen-specific Treg cells rapidly move into the antigen injected site in CCR2 dependent manner. Moreover, prior treatment with antigen and IL-2 ICs enhanced antigen-specific Treg-cell migration and inhibited delayed type hypersensitivity (DTH) reactions. Thus, the treatment with Ag and IL-2 ICs can efficiently expand Ag-specific Treg cells with the capacity to migrate and reduce localized immune responses.
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| Free Research Field |
免疫学
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