The role of HIF-1a in the influenza infection

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860776
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: IKEJIRI Ai 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 (30528295)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Influenza / HIF-1a / Dendritic cells

Outline of Final Research Achievements

H5N1 high pathogenic avian influenza causes elevated mortality and acute respiratory distress syndrome (ARDS). I focused on the antigen presenting cell, dendritic cells, which have an important roll of the production of antibody against virus. In H5N1 infection, the number of dendritic cells interacted with T cells was decreased and impaired the production of antibody. Furthermore, H5N1 vaccine based on Vaccinia virus protected effectively against H5N1 infection due to the increase of the number of dendritic cells interacted with T cells and the induction of antibody. I identified the mechanism of associated with the severe symptoms seen with H5N1 infection.

Free Research Field

感染免疫