Role of DENN domain proteins in the development of neuroblastoma cancer stem cells.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860801
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Kobe University
• Principal Investigator: Yamamoto Nobuyuki 神戸大学, 医学部附属病院, 助教 (20596043)
• Research Collaborator: Nishimura Noriyuki 神戸大学, 大学院, 特命教授 (00322719) ; Hayakawa Akira 神戸大学, 大学院, 准教授 (40379376) ; Kosaka Yoshiyuki 兵庫県立こども病院, 血液腫瘍科, 部長 ; Yanai Tomoko 兵庫県立こども病院, 血液腫瘍科, 医長
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 神経芽腫 / 細胞内小胞輸送 / 低分子量G蛋白質 / DENNドメイン蛋白質

Outline of Final Research Achievements

More than half of high-risk neuroblastoma patients experience tumor relapses and less than 40% can expect a long-term survival. Intracellular vesicle transport seems to play an important role on the development of neuroblastoma cancer stem cells that are responsible for tumor relapses. In this study, we focused on DENN domain proteins, regulators of intracellular vesicle transport, and revealed that a member of DENN domain proteins is involved in the progression of neuroblastoma.

Free Research Field

小児血液腫瘍学