Analysis of the mechanisms of the susceptibility to staphylococcal infection in a mouse model of Hyper-IgE syndrome

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860808
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: WADA Takeshi 徳島大学, 疾患プロテオゲノム研究センター, 特任助教 (80583418)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 高ＩｇＥ症候群 / 黄色ブドウ球菌

Outline of Final Research Achievements

To investigate the molecular mechanism underlying the susceptibility to S. aureus infection in patients of Hyper-IgE syndrome (HIES), we established a mouse model of HIES. We found that recruitment of neutrophils and production of chemoattractants were impaired in the skin lesions of these mice infected with S. aureus. Furthermore, production of IL-17A by CD3+TCRγδ+ cells and CD3+CD4+ cells were also decreased compared to WT mice. Since it has been reported that neutrophil and IL-17A are essential for elimination of S. aureus, impaired neutrophil response and IL-17A production might lead to the susceptibility to staphylococcal infection in HIES.

Free Research Field

免疫学