2016 Fiscal Year Final Research Report
Reference value development of the glomerular filtration rate of the low birth weight infants using the plasma inulin clearance
| Project/Area Number |
26860825
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
MURANO Yayoi 順天堂大学, 医学部, 非常勤助教 (80771922)
NAKAGAWA Mayu 順天堂大学, 医学部, 非常勤助教
HIRANO Daishi 東京慈恵会医科大学, 医学部, 助教 (90424663)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 早産児 / 低出生体重児 / ネフロン / 慢性腎障害 / 未熟網膜症 / 酸素毒性 / DOHaD |
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| Outline of Final Research Achievements |
In this study, we examined chronic renal impairment after the growth of the premature infants. First, urinary angiotensinogen (AGT) elevation prior to urinary protein levels is an useful biomarker to detect kidney impairment related prematurity. Second, renal impairment was caused by exposure to a hyperoxic environment during nephrogenesis, and the pathology of the impaired nephrogenesis in this oxygen-induced retinopathy animal model reflects the characteristics of retinopathy of prematurity observed in preterm infants.
From these findings, the clinicians should observe renal function after the growth of the premature infants carefully.
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| Free Research Field |
小児腎臓、新生児医療
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