2016 Fiscal Year Final Research Report
Analysis of right ventricle histopathology from human heart specimen of pulmonary arterial hyoertension
| Project/Area Number |
26860841
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Iwasa Toru 国立研究開発法人国立循環器病研究センター, 病院, 医師 (80712843)
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| Research Collaborator |
YAMADA Osamu
SHIRAISHI Isao
UEDA Hatsue
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肺高血圧 / 右心不全 / 右室病理 / 右室リモデリング |
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| Outline of Final Research Achievements |
From the analysis of specimens from pulmonary arterial hypertension patients, the fibrotic area percentage in the right ventricle was significantly about 4 times larger from the normal right ventricle and small arteries in right ventricle were significantly reduced. These findings were emphasized at endocardical side of the right ventricle.The fibrotic area percentage was not correlated with the hemodynamic data of the patients, but correlated with the number of years from the beginning of the symptom to the time of diagnosis or death.
The thickness of the right coronary arteries which mainly perfuse right ventricles related to the symptom of heart failure.
To manage the pulmonary arterial hypertension better, it is important to diagnose the disease as early as possible to reduce the fibrosis of the right ventricle, and it is also important to evaluate the thickness of right coronary arteries.
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| Free Research Field |
小児循環器
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