Additional new therapy for neonatal hypoxic-ischemic encephalopathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860847
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨床研究部(循環器)) (2015-2016); Kagawa University (2014)
• Principal Investigator: Jinnai Wataru 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨, 小児科, 医師 (10595929)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 新生児低酸素性虚血性脳症 / 脳血液量 / 脳波 / 新生児仮死 / 低体温療法 / 新生仔豚 / 新生児脳症 / 脳組織ヘモグロビン酸素飽和度

Outline of Final Research Achievements

The aim of study is to develop additional new therapy following hypothermia (HT) for hypoxic ischemic encephalopathy (HIE). To classify the HIE neonates who cannot be improved by only HT, we examined the relationship between changes in cerebral blood volume (CBV) and the low amplitude-integrated electroencephalography (LAEEG) duration during hypothermia in asphyxiated piglets using time-resolved spectroscopy (TRS) and EEG. The following results had been reported. There was a positive linear correlation between changes in CBV and LAEEG duration within 24h after HI insult during normothermia. Otherwise, during HT, there was a negative linear correlation between them within 24h after insult. Since, we may be able to identify HIE neonate with risk factors for poor prognosis during HT requiring additional therapy due to evaluating change in both CBV and neural activity using TRS and EEG.

Free Research Field

新生児医療